1906

• J. Stuart Blackton's Humorous Phases of Funny Faces

1908

• Emil Cohl's Fantasmagoric

1911

• Winsor McCay animates Little Nemo

1912

• McCay's second film, The Story of a Mosquito, released

1913

• First (limited) animation comic strips appear as supplement in newsreels: The Newlyweds, Mutt and Jeff, Colonel Heeza Liar
• J.R. Bray's earliest films released

1914

• McCay introduces Gertie the Dinosaur to vaudeville audiences.
• J.R. Bray and Earl Hurd apply for patents to simplify cartoon production techniques by using cels.

1916

• Krazy Kat series begins in Hearst Vitagraph News Pictorial
• J.R. Bray produces Paul Terry's Farmer Al Falfa cartoons
• The Katzenjammer Kids series begins

1918

• First Max Fleischer rotoscope experiments released
• Winsor McCay's Sinking of the Lusitania released

1919

• First Max Fleischer Out of the Inkwell cartoons, with KoKo the Clown, released
• First appearance of Felix the Cat in Feline Follies

1921

• Van Beuren's Aesop's Film Fables begin, with Paul Terry and John Foster as directors

1923

• Walt Disney's Alice comedies begin

1924

• Max Fleischer releases experimental sound Song Cartoons and begins series of Bouncing Ball cartoons for Bray

1926

• Adventures of Prince Achmed is first animated feature, by Lotte Reiniger, produced in Germany

1927

• Disney's Oswald the Lucky Rabbit series debuts

1928

• Disney and Ub Iwerks create first three Mickey Mouse cartoons: Plane Crazy, The Gallopin' Gaucho, and Steamboat Willie

1929

• First Silly Symphonies cartoon, The Skeleton Dance, released

1930

• Leon Schlesinger produces first Looney Tune, Hugh Harman and Rudolph Ising's Sinkin' in the Bathtub, starring Bosko
• Fleischer's Betty boop appears in Dizzy Dishes and Barnacle Bill
• First Technicolor cartoon sequence by Walter Lantz in King of Jazz